Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin
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RED CELLS Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin
Adaptive mechanisms to hematocrit levels of 0.9 in our erythropoietin-overexpressing mice (tg6) include increased plasma nitric oxide levels and erythrocyte flexibility. Doubled reticulocyte counts in tg6 suggest an increased erythrocyte turnover. Here we show that compared with wild-type (wt) animals, erythrocyte lifespan in tg6 is 70% lower in tg6 mice. Transgenic mice have a younger erythroc...
متن کاملEnhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin.
Adaptive mechanisms to hematocrit levels of 0.9 in our erythropoietin-overexpressing mice (tg6) include increased plasma nitric oxide levels and erythrocyte flexibility. Doubled reticulocyte counts in tg6 suggest an increased erythrocyte turnover. Here we show that compared with wild-type (wt) animals, erythrocyte lifespan in tg6 is 70% lower in tg6 mice. Transgenic mice have a younger erythroc...
متن کاملScientific category: RED CELLS Enhanced erythro-phagocytosis in polycythemic mice overexpressing erythropoietin
(1174 articles) Red Cells (3094 articles) Hematopoiesis and Stem Cells Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repri...
متن کاملEnhanced susceptibility to suicidal death of erythrocytes from transgenic mice overexpressing erythropoietin.
Eryptosis, a suicidal death of mature erythrocytes, is characterized by decrease of cell volume, cell membrane blebbing, and breakdown of cell membrane asymmetry with phosphatidylserine exposure at the cell surface. Triggers of eryptosis include increased cytosolic Ca(2+) activity, which could result from activation of Ca(2+)-permeable cation channels. Ca(2+) triggers phosphatidylserine exposur...
متن کاملNorepinephrine-induced acute heart failure in transgenic mice overexpressing erythropoietin.
OBJECTIVE Overexpression of erythropoietin (Epo) in mice (Epo-tg6) leads to an increase in hematocrit and blood volume, and strongly reduces endurance upon exercise. It was the aim of this study to characterize the mechanisms underlying the reduced cardiac performance. METHODS Left (LV) and right (RV) ventricular function was measured with and without norepinephrine (NE) stimulation in 12 ana...
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ژورنال
عنوان ژورنال: Blood
سال: 2007
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2006-12-063602